Lithium hydroxide, monohydrate → 2-[3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid
반응식
O.[OH-].[Li+].C([O:6][C:7](=[O:18])[CH2:8][N:9]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[N:10]1)C>O.C1COCC1>[F:17][C:14]([F:15])([F:16])[C:11]1[CH:12]=[CH:13][N:9]([CH2:8][C:7]([OH:18])=[O:6])[N:10]=1참가 물질
5
실험 절차
Lithium hydroxide monohydrate (127 mg, 3.03 mmol) in water (0.5 mL) was added to (3-(trifluoromethyl)-1H-pyrazol-1-yl)acetic acid ethyl ester (250 mg, 1.125 mmol) in THF (5 mL). The mixture was stirred at room temperature for 5 hours then the reaction mixture volume was reduced to one third by evaporation in vacuo. The aqueous residue was acidified using aqueous HCl (2M) to pH=5. The resulting off white solid was filtered, collected and dried, washed with ether to afford the title compound as a white solid (42 mg, 19%).
후처리
- customthe reaction mixture volume was reduced to one third by evaporation in vacuo
- filtrationThe resulting off white solid was filtered
- customcollected
- customdried
- washwashed with ether
출처 및 근거
- ORD 기록
- ord-9d52e78fb76b4841946e366f86da170a
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09163021B2
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