Hydrochloric Acid → 1-(2-Chloro-6-hydroxyphenyl)ethan-1-one

HRID 1753965노트

반응식

HRID 1753965 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8]COC)[C:3]=1[C:12](=[O:14])[CH3:13].Cl>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[C:3]=1[C:12](=[O:14])[CH3:13]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 669605601-[2-Chloro-6-(methoxymethoxy)phenyl]ethanone

생성물 1

HCID 5934151-(2-Chloro-6-hydroxyphenyl)ethan-1-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
65 °C

실험 절차

To a solution of 1-(2-chloro-6-(methoxymethoxy)phenyl)ethanone (38 g, 177.03 mmol, 1.00 equiv) in THF (380 mL) was added HCl (aq. 35 g, 2.00 equiv, 36%). The resulting mixture was allowed to react, with stirring, for 3 h at 65° C. The resulting mixture was extracted with ethyl acetate. The organic phase was separated, dried and concentrated under vacuum to give the crude title compound.

후처리

  1. customto react
  2. extractionThe resulting mixture was extracted with ethyl acetate
  3. customThe organic phase was separated
  4. customdried
  5. concentrationconcentrated under vacuum

출처 및 근거

ORD 기록
ord-03868c8c1c2a46798ba082f6f08f4fe3
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09168248B2

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