Phosphorus tribromide → 5-(Bromomethyl)-1-methyl-1H-benzotriazole
반응식
P(Br)(Br)[Br:2].[CH3:5][N:6]1[C:10]2[CH:11]=[CH:12][C:13]([CH2:15]O)=[CH:14][C:9]=2[N:8]=[N:7]1>C(OCC)C.O>[Br:2][CH2:15][C:13]1[CH:12]=[CH:11][C:10]2[N:6]([CH3:5])[N:7]=[N:8][C:9]=2[CH:14]=1참가 물질
5
실험 절차
Phosphorus tribromide (0.230 ml, 2.45 mmol) is added to a stirred solution of (1-methyl-1H-1,2,3-benzotriazole-5-yl)methanol (0.4 g, 2.45 mmol) in diethyl ether (25 ml) under an inert atmosphere of Argon. After stirring overnight at room temperature, the reaction mixture is diluted with water (5 ml) and stirred vigorously for 10 minutes. The organic portion is separated, washed with water (2×5 ml), brine (2×5 ml) and concentrated in vacuo to yield the titled product which is used crude in the next step. (MH+226).
후처리
- stirringstirred vigorously for 10 minutes
- customThe organic portion is separated
- washwashed with water (2×5 ml), brine (2×5 ml)
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-be6a705bdd954863b4fff2d7bd9691a7
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09169251B2
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