Water → 2-Bromo-5-isocyanato-1,3-dimethylbenzene
반응식
ClC(Cl)(O[C:5](=[O:11])OC(Cl)(Cl)Cl)Cl.[Br:13][C:14]1[C:19]([CH3:20])=[CH:18][C:17]([NH2:21])=[CH:16][C:15]=1[CH3:22].O>O1CCOCC1>[Br:13][C:14]1[C:19]([CH3:20])=[CH:18][C:17]([N:21]=[C:5]=[O:11])=[CH:16][C:15]=1[CH3:22]참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
Triphosgene (2.23 g, 7.52 mmol) was added to a solution of 4-bromo-3,5-dimethyl-phenylamine (4.3 g, 21.49 mmol) in dioxane (71 ml). After stirring at 100° C. for 15 hours, water was added to the reaction solution. After extraction with ethyl acetate, the organic phase was sequentially washed with water and saturated brine and concentrated under reduced pressure to give 2-bromo-5-isocyanato-1,3-dimethylbenzene (2.0 g, 41%).
후처리
- extractionAfter extraction with ethyl acetate
- washthe organic phase was sequentially washed with water and saturated brine
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-fb602089dde1444fa16869f3eea4d148
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09169254B2
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