Dimethylformamide → 6-Amino-3-bromo-4-fluoro-2-methylbenzonitrile
반응식
[Br:1]N1C(=O)CCC1=O.CN(C)C=O.[NH2:14][C:15]1[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([CH3:24])[C:16]=1[C:17]#[N:18]>O>[NH2:14][C:15]1[C:16]([C:17]#[N:18])=[C:19]([CH3:24])[C:20]([Br:1])=[C:21]([F:23])[CH:22]=1참가 물질
5
실험 절차
N-Bromosuccinimide (16.6 g, 93.3 mmol) was gradually added to an N,N-dimethylformamide (250 ml) solution of 2-amino-4-fluoro-6-methylbenzonitrile (I-264) (14.0 g, 93.3 mmol). After stirring for 6 hours, the reaction liquid was poured into water with ice (750 ml), the precipitated solid was collected by filtration. The solid was washed with water, then dried to obtain the entitled compound (20.2 g, 95%) as a gray solid.
후처리
- customthe reaction liquid
- filtrationthe precipitated solid was collected by filtration
- washThe solid was washed with water
- customdried
출처 및 근거
- ORD 기록
- ord-dc698879c22a4075bb6d951fdb6285db
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07737166B2
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