Sodium Hydroxide → 2-Phenyl-oxazole-4-carboxylic acid
반응식
C([O:3][C:4]([C:6]1[N:7]=[C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[O:9][CH:10]=1)=[O:5])C.[OH-].[Na+]>C1COCC1.CO.CCOC(C)=O>[C:11]1([C:8]2[O:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1참가 물질
6
실험 절차
2-Phenyl-oxazole-4-carboxylic acid ethyl ester (500 mg, 2.30 mmol) was dissolved in a mixture of THF (2.3 mL) and MeOH (2.3 mL). To this was added NaOH (10% aqueous, 2.3 mL). The reaction mixture was stirred for 2 h, and was then diluted with EtOAc and washed with 1N HCl The aqueous layer was extracted with EtOAc and the combined organics were dried over Na2SO4, filtered and concentrated to give the product as a white solid (366 mg, 84%).
후처리
- washwashed with 1N HCl The aqueous layer
- extractionwas extracted with EtOAc
- dry with materialthe combined organics were dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-2375a725800040b5ab5f592111fdc2d1
- 출처 데이터셋
- uspto-grants-2015_10
- 특허 번호
- US09169261B2
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