Hydrochloric Acid → (S)-2-Amino-N-(3-(5-formylthiazol-2-ylamino)propyl)propanamide

HRID 1755466노트

반응식

HRID 1755466 반응식
[CH:1]([C:3]1[S:7][C:6]([NH:8][CH2:9][CH2:10][CH2:11][NH:12][C:13](=[O:24])[C@@H:14]([NH:16]C(=O)OC(C)(C)C)[CH3:15])=[N:5][CH:4]=1)=[O:2].Cl.C(OCC)C>C(Cl)Cl>[NH2:16][C@@H:14]([CH3:15])[C:13]([NH:12][CH2:11][CH2:10][CH2:9][NH:8][C:6]1[S:7][C:3]([CH:1]=[O:2])=[CH:4][N:5]=1)=[O:24]

참가 물질

5

반응물 3

HCID 313Hydrochloric Acid2회HCID 3283Diethyl EtherHCID 86700112(S)-tert-Butyl 1-(3-(5-formylthiazol-2-ylamino)propylamino)-1-oxopropan-2-ylcarbamate

생성물 1

HCID 86700111(S)-2-Amino-N-(3-(5-formylthiazol-2-ylamino)propyl)propanamide수율 137.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Following the procedure as described in Example 68, except using material from Example 69 (265 mg, 0.743 mmol), CH2Cl2 (50 mL), HCl, 11.0M in diethyl ether (5 mL, 5.00 mmol) and stirring at room temp for 2.5 days, 262 mg (quantitative yield) of the title compound is obtained as a pale yellow solid, as a bis HCl salt by weight. LC/MS (Condition A): ret. T=0.93 min, (M+H)+ 257.14.

출처 및 근거

ORD 기록
ord-691d65edd76342adb9ba7fca985f8d8c
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09169295B2

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