Hydrochloric Acid → (S)-1-(5-Formylthiazol-2-yl)pyrrolidine-2-carboxylic acid

HRID 1755472노트

반응식

HRID 1755472 반응식
[CH:1]([C:3]1[S:7][C:6]([N:8]2[CH2:12][CH2:11][CH2:10][C@H:9]2[C:13]([O:15]C(C)(C)C)=[O:14])=[N:5][CH:4]=1)=[O:2].Cl.CCOCC>C(Cl)Cl>[CH:1]([C:3]1[S:7][C:6]([N:8]2[CH2:12][CH2:11][CH2:10][C@H:9]2[C:13]([OH:15])=[O:14])=[N:5][CH:4]=1)=[O:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric Acid2회HCID 3283Diethyl EtherHCID 131733675(S)-ter-Butyl 1-(5-formylthiazol-2-yl)pyrrolidine-2-carboxylate

생성물 1

HCID 89858146(S)-1-(5-Formylthiazol-2-yl)pyrrolidine-2-carboxylic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Following the procedure as described in Example 68, except using material from Example 79 (33.4 mg, 0.118 mmol), anhydrous CH2Cl2 (3 mL), HCl, 1.0M in Et2O (6 mL, 6.0 mmol) stirring at room temp for 48 h, the title compound (quantitative yield) is isolated as an HCl salt that is used directly “as is” in the next step. LC/MS (Condition A): ret. T=1.88 min, (M+H)+ 227.05.

출처 및 근거

ORD 기록
ord-e83a2aeea0bc44638ad264c6d5341e35
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09169295B2

반응 노트

불러오는 중…