Tert-Butylamine → Methyl 2-(tert-butylamino)acetate

HRID 1755629노트

반응식

HRID 1755629 반응식
Br[CH2:2][C:3]([O:5][CH3:6])=[O:4].[C:7]([NH2:11])([CH3:10])([CH3:9])[CH3:8]>CCOCC>[C:7]([NH:11][CH2:2][C:3]([O:5][CH3:6])=[O:4])([CH3:10])([CH3:9])[CH3:8]

참가 물질

4

반응물 2

HCID 6385Tert-ButylamineHCID 60984Methyl bromoacetate

생성물 1

HCID 2777439Methyl 2-(tert-butylamino)acetate수율 96.6%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Methyl bromoacetate (7.1 mL, 75 mmol) is added dropwise to tert-butylamine (31.5 mL, 300 mmol) at 0° C. The reaction mixture is diluted with ether, warmed to room temperature and filtered. The filtrate is concentrated in vacuo to obtain the title product as a clear liquid (10.52 g) which is identified by 1H and 13CNMR spectral analyses.

후처리

  1. filtrationfiltered
  2. concentrationThe filtrate is concentrated in vacuo

출처 및 근거

ORD 기록
ord-7696b52d36c942eca84a552daf349118
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05438035

반응 노트

불러오는 중…