Hydrogen Bromide → 2,3-Dimethyl-7-(o-methoxyphenacyl)pyrrolo[2,3-b]pyridine

반응식

[CH3:1][C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[CH3:11].[CH3:12][O:13][C:14]1[CH:23]=[CH:22][CH:21]=[CH:20][C:15]=1[C:16](=[O:19])[CH2:17]Br.Br>>[CH3:1][C:2]1[N:10]=[C:5]2[N:6]([CH2:17][C:16]([C:15]3[CH:20]=[CH:21][CH:22]=[CH:23][C:14]=3[O:13][CH3:12])=[O:19])[CH:7]=[CH:8][CH:9]=[C:4]2[C:3]=1[CH3:11]

참가 물질

반응물 3

HCID 260Hydrogen Bromide

HCID 123440Bromomethyl 2-methoxyphenyl ketone

HCID 125323872,3-Dimethyl-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 199167932,3-Dimethyl-7-(o-methoxyphenacyl)pyrrolo[2,3-b]pyridine

실험 절차

The title compound was prepared on a 1 mmol scale from 2,3-dimethylpyrrolo[2,3-b]pyridine and o-methoxyphenacyl bromide in the same manner as described in example 27 yielding 244 mg (71%) pure hydrobromide as a light yellow solid.

출처 및 근거

ORD 기록: ord-ffa9b6dd3c774b4dbf54e9fb3c43fc98
출처 데이터셋: uspto-grants-1995_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05439917

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