Lithium Hydroxide → HCID 15341834, 화합물

HRID 1756219노트

반응식

HRID 1756219 반응식
[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([O:20]CC)=[O:19])=[C:6]([CH2:31][CH:32]=[CH2:33])[C:5]=1[O:34][CH3:35])=[O:3].[OH-].[Li+]>CO>[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([OH:20])=[O:19])=[C:6]([CH2:31][CH:32]=[CH2:33])[C:5]=1[O:34][CH3:35])=[O:3]

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 15341833HCID 15341833, 화합물

생성물 1

HCID 15341834HCID 15341834, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The compound of Example 55 (100 mg, 0,195 mmol) and 390 μl of 1M lithium hydroxide (0.3896 mmol) were added to 2.0 ml of methanol, and the reaction mixture was stirred at room temperature for 4 hours. The solvent was removed under vacuum, 5.0 ml of water was added to the residue, and the mixture was acidified with 10% hydrochloric acid. The mixture was filtered, and the white solid which was recovered was dried in a 40° C. oven overnight to give the product.

후처리

  1. customThe solvent was removed under vacuum, 5.0 ml of water
  2. additionwas added to the residue
  3. filtrationThe mixture was filtered
  4. customthe white solid which was recovered
  5. customwas dried in a 40° C. oven overnight
  6. customto give the product

출처 및 근거

ORD 기록
ord-887375d1d2a8445bb77788b57fa3ffe0
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05439937

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