Lithium Hydroxide → HCID 15341844, 화합물

HRID 1756229노트

반응식

HRID 1756229 반응식
[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([O:20]CC)=[O:19])=[C:6]([CH2:31][CH:32]2[CH2:34][CH2:33]2)[C:5]=1[O:35][CH3:36])=[O:3].[OH-].[Li+]>C(OCC)(=O)C.CO.C(O)(=O)C>[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([OH:20])=[O:19])=[C:6]([CH2:31][CH:32]2[CH2:34][CH2:33]2)[C:5]=1[O:35][CH3:36])=[O:3]

참가 물질

4

반응물 2

HCID 3939Lithium HydroxideHCID 19026443HCID 19026443, 화합물

생성물 1

HCID 15341844HCID 15341844, 화합물

시약·촉매·용매 1

HCID 22023684HCID 22023684, 화합물용매

실험 절차

The compound of Example 71 is saponified with lithium hydroxide using the conditions described in Example 26. Chromatography of the crude residue on silica gel using ethyl acetate/methanol/acetic acid as eluant (90:9.5:0.5) affords the product.

후처리

  1. customaffords the product

출처 및 근거

ORD 기록
ord-1cde39223fe946c48f2764784dc23fbb
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05439937

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