Butyl chloroformate → Methyl 4-[6-(butoxycarbonyl)aminobenzimidazol-1-ylmethyl]-3-methoxybenzoate

HRID 1756386노트

반응식

HRID 1756386 반응식
Cl[C:2]([O:4][CH2:5][CH2:6][CH2:7][CH3:8])=[O:3].[NH2:9][C:10]1[CH:11]=[CH:12][C:13]2[N:17]=[CH:16][N:15]([CH2:18][C:19]3[CH:28]=[CH:27][C:22]([C:23]([O:25][CH3:26])=[O:24])=[CH:21][C:20]=3[O:29][CH3:30])[C:14]=2[CH:31]=1>>[CH2:5]([O:4][C:2]([NH:9][C:10]1[CH:11]=[CH:12][C:13]2[N:17]=[CH:16][N:15]([CH2:18][C:19]3[CH:28]=[CH:27][C:22]([C:23]([O:25][CH3:26])=[O:24])=[CH:21][C:20]=3[O:29][CH3:30])[C:14]=2[CH:31]=1)=[O:3])[CH2:6][CH2:7][CH3:8]

참가 물질

3

반응물 2

HCID 61140Butyl chloroformateHCID 14763098Methyl 4-(6-aminobenzimidazol-1-ylmethyl)-3-methoxybenzoate

생성물 1

HCID 23365847Methyl 4-[6-(butoxycarbonyl)aminobenzimidazol-1-ylmethyl]-3-methoxybenzoate수율 34%

실험 절차

Using a similar procedure to that described in Example 35, but using butyl chloroformate and (J) , the title compound was obtained as a solid in 34% yield; partial NMR: 0.9(t,3H, CH3CH2), 1.4(m,2H, CH3CH2) , 1.6 (m, 2H, CH2CH2O), 4.1 (t, 2H, CH2O).

출처 및 근거

ORD 기록
ord-7c9e3f2a534c42f8818f8770ed9b4e1e
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05440035

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