Water → 6-Nitroquinoline-2-carboxylic acid

HRID 1756505노트

반응식

HRID 1756505 반응식
[CH:1](=[C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N+:18]([O-:20])=[O:19])[CH:14]=2)[NH:9]1)C1C=CC=CC=1.[O-:21][Mn](=O)(=O)=O.[K+].[OH2:27]>N1C=CC=CC=1>[C:1]([C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([N+:18]([O-:20])=[O:19])[CH:14]=2)[N:9]=1)([OH:21])=[O:27]

참가 물질

5

반응물 3

HCID 962WaterHCID 516875Potassium PermanganateHCID 67619679HCID 67619679, 화합물

생성물 1

HCID 123242586-Nitroquinoline-2-carboxylic acid수율 39%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of 2-benzylidene-6-nitroquinoline (4.9 g; 17.7 mM) in pyridine (36.6 ml) and water (8 ml) was added portion wise KMnO4 (7.5 g; 47.8 mM) keeping the temperature between 18 and 20° C. After filtration on celite, the solution was acidified (pH3), at 0° C., with H2SO4 (65%). The resulting precipitate was filtered, washed with water and ether and then dried to give 2-carboxy-6-nitroquinoline (1.5 g; 39%).

후처리

  1. customthe temperature between 18 and 20° C
  2. filtrationAfter filtration on celite
  3. customat 0° C.
  4. filtrationThe resulting precipitate was filtered
  5. washwashed with water and ether
  6. customdried

출처 및 근거

ORD 기록
ord-7aa3c28a5ebf48368cae92f6cd761c7f
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05441949

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