4-Chloro-2-nitro-1-(phenylthio)benzene → 5-Chloro-2-phenylsulfanyl-phenylamine

HRID 1756555노트

반응식

HRID 1756555 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[C:4]([N+:15]([O-])=O)[CH:3]=1.[H][H]>[Ni].C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[C:4]([NH2:15])[CH:3]=1

참가 물질

5

반응물 2

HCID 3769774-Chloro-2-nitro-1-(phenylthio)benzeneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 20637175-Chloro-2-phenylsulfanyl-phenylamine수율 88.2%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

A solution of 4-chloro-2-nitro-1-(phenylthio)benzene (11.0 g) and Raney nickel in ethanol (3A; 9.3 mL) was reacted in a Parr Hydrogenator under hydrogen atmosphere at 5 psi and room temperature. When the theoretical amount of hydrogen uptake was reached, the reaction was filtered to remove the catalyst and evaporated in vacuo to yield 8.61 g (88%) of a light orange solid. mp: 59°-61° C.

후처리

  1. filtrationthe reaction was filtered
  2. customto remove the catalyst
  3. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-eed8fa0ac01a4b11a6cee8716d2356b8
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05441950

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