Hydrochloric Acid → (E)-2-(Hydroxyimino)-N-methyl-2-(2-phenoxyphenyl)acetamide

HRID 1756742노트

반응식

HRID 1756742 반응식
[NH2:1][OH:2].[CH3:3][NH:4][C:5](=[O:21])[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=O.Cl>C1(C)C=CC=CC=1>[CH3:3][NH:4][C:5](=[O:21])/[C:6](/[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[N:1]/[OH:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 787HydroxylamineHCID 11780091N-methyl-2-(2-phenoxyphenyl)-2-oxoacetamide

생성물 1

HCID 9816878(E)-2-(Hydroxyimino)-N-methyl-2-(2-phenoxyphenyl)acetamide수율 98%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Toluene (20 ml) and a 50% aqueous solution (0.71 ml, 12 mmol) of hydroxylamine were added to N-methyl-2-(2-phenoxyphenyl)-2-oxoacetamide (2.55 g, 10 mmol). The mixture was heated under reflux for 4 hours (E/Z=40/60). After cooling, conc. hydrochloric acid (3.0 ml, 30 mmol) was added, and the mixture was stirred at room temperature for 24 hours. After completion of the reaction, the resulting crystals were separated by filtration, washed with water and toluene and dried to give (E)-N-methyl-2-(2-phenoxyphenyl)-2-hydroxyiminoacetamide (2.65 g, Yield: 98.0%, E/Z=98/2).

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 4 hours (E/Z=40/60)
  3. temperatureAfter cooling
  4. customAfter completion of the reaction
  5. customthe resulting crystals were separated by filtration
  6. washwashed with water and toluene
  7. customdried

출처 및 근거

ORD 기록
ord-3bd77effff06463a86bad3004dca5749
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05442063

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