Bis(4-hydroxyphenyl)methane → HCID 20510578, 화합물

HRID 1758203노트

반응식

HRID 1758203 반응식
[CH2:1]([N:5]1[C:9](=[O:10])[C:8]2([CH2:15][C:14]([CH3:17])([CH3:16])[N:13]([CH2:18][CH:19]3[O:21][CH2:20]3)[C:12]([CH3:23])([CH3:22])[CH2:11]2)[NH:7][C:6]1=[O:24])[CH2:2][CH2:3][CH3:4].[OH:25][C:26]1[CH:31]=[CH:30][C:29]([CH2:32][C:33]2[CH:38]=[CH:37][C:36]([OH:39])=[CH:35][CH:34]=2)=[CH:28][CH:27]=1.[H-].[Na+]>C(O)CC(C)C>[CH2:1]([N:5]1[C:9](=[O:10])[C:8]2([CH2:11][C:12]([CH3:22])([CH3:23])[N:13]([CH2:18][CH:19]([OH:21])[CH2:20][O:25][C:26]3[CH:27]=[CH:28][C:29]([CH2:32][C:33]4[CH:38]=[CH:37][C:36]([O:39][CH2:20][CH:19]([OH:21])[CH2:18][N:13]5[C:14]([CH3:17])([CH3:16])[CH2:15][C:8]6([NH:7][C:6](=[O:24])[N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[C:9]6=[O:10])[CH2:11][C:12]5([CH3:22])[CH3:23])=[CH:35][CH:34]=4)=[CH:30][CH:31]=3)[C:14]([CH3:17])([CH3:16])[CH2:15]2)[NH:7][C:6]1=[O:24])[CH2:2][CH2:3][CH3:4]

참가 물질

5

반응물 3

HCID 12111Bis(4-hydroxyphenyl)methaneHCID 24758Sodium hydrideHCID 20510596HCID 20510596, 화합물

생성물 1

HCID 20510578HCID 20510578, 화합물

시약·촉매·용매 1

HCID 31260Isoamyl Alcohol용매

실험 절차

A mixture of 4.0 g of 3-butyl-8-(2,3-epoxypropyl)-7,7,9,9-tetramethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione and 1.0 g of bis(p-hydroxyphenyl)methane in 5 ml of isopentyl alcohol with a catalytic amount of sodium hydride was refluxed for 10 hours. After completion of the reaction, the residue obtained by evaporating the solvent under reduced pressure from the reaction mixture was purified by column chromatography through silica gel eluted with a 1:1 by volume mixture of benzene and ethyl acetate, giving the desired Compound No. 351 in the form of white crystals melting at 202°-204° C.

후처리

  1. temperaturewas refluxed for 10 hours
  2. customAfter completion of the reaction
  3. customthe residue obtained
  4. customby evaporating the solvent under reduced pressure from the reaction mixture
  5. customwas purified by column chromatography through silica gel
  6. washeluted with a 1:1 by volume mixture of benzene and ethyl acetate

출처 및 근거

ORD 기록
ord-ede89440b52340ad8bbc0763d430f07c
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04371644

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