Sodium Hydroxide → 2-Cyano-3,3-diphenyl-2-propenoic acid

HRID 1758357

반응식

HRID 1758357 반응식
[C:1]1([C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:8]([C:14]#[N:15])[C:9]([O:11]CC)=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO.O>[C:1]1([C:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[C:8]([C:14]#[N:15])[C:9]([OH:11])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 243274Etocrylene

생성물 1

HCID 98378162-Cyano-3,3-diphenyl-2-propenoic acid

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

반응 조건

온도
20 °C

실험 절차

To 200 ml. of methanol:water (1:4) solution containing 55 g. (0.2 mole) of ethyl β,β-diphenyl-α-cyanoacrylate (CYASORB N-35, American Cyanamid), 18 g. of 50% NaOH (0.22 mole) is added and the soluton is stirred at about 20° C. overnight. After it is washed with ether, the aqueous solution is neutralized with dilute HCl to precipitate the product. The yield is 48 g., 97%, m.p., 207°-209° C.

후처리

  1. washAfter it is washed with ether
  2. customto precipitate the product
  3. custom97%, m.p., 207°-209° C.

출처 및 근거

ORD 기록
ord-2554c545361e402f855e186f59d661a8
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04373060

연결된 노트

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