(2-((Dimethylamino)methyl)thiazol-4-yl)methanol → HCID 178482517, 화합물

HRID 1758635

반응식

HRID 1758635 반응식
[CH3:1][NH:2][C:3]1[C:7]([NH:8][CH2:9][CH2:10][SH:11])=[N:6][S:5](=[O:13])(=[O:12])[N:4]=1.[CH3:14][N:15]([CH2:17][C:18]1[S:19][CH:20]=[C:21]([CH2:23]O)[N:22]=1)[CH3:16]>Cl>[CH3:14][N:15]([CH2:17][C:18]1[S:19][CH:20]=[C:21]([CH2:23][S:11][CH2:10][CH2:9][NH:8][C:7]2[C:3]([NH:2][CH3:1])=[N:4][S:5](=[O:13])(=[O:12])[N:6]=2)[N:22]=1)[CH3:16]

참가 물질

4

반응물 2

HCID 1838020(2-((Dimethylamino)methyl)thiazol-4-yl)methanolHCID 178482512HCID 178482512, 화합물

생성물 1

HCID 178482517HCID 178482517, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

Reaction of 3-methylamino-4-(2-mercaptoethylamino)-1,2,5-thiadiazole 1,1-dioxide [prepared in Example 25, Step A] with about one equivalent of 2-dimethylaminomethyl-4-hydroxymethylthiazole [prepared in Example 34, Step D] in concentrated hydrochloric acid, and then made basic and worked up, produces the title compound which is identical to the product prepared in Example 33.

출처 및 근거

ORD 기록
ord-8b67ff6647a0405396011910233436e5
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04374248

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