Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 7-[3-[4-(3-Phenylthio-propyl)-1-piperazinyl]-propyl]-theophylline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 7-(3-Chloropropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione | HCID 76011 | — |
| 반응물 | 1-(3-(Phenylthio)propyl)piperazine | HCID 2195492 | — |
| 생성물 | 7-[3-[4-(3-Phenylthio-propyl)-1-piperazinyl]-propyl]-theophylline | HCID 3061739 | — |
반응 단계
7-(3-Chloropropyl)-theophylline (1 mole) and 1-(3-phenylthiopropyl)-piperazine are refluxed for 24 hours in a 50% aqueous-alcoholic solution. On completion of the reaction, sodium hydroxide (1 mole) is then added. The mixture is extracted with methylene chloride and washed with water, after which the solvent is evaporated off and the residue is recrystallized from ethanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04374835 |
| 출처 데이터셋 | uspto-grants-1983_02 |
| ORD ID | ord-ff943f179a204bf99252551d0e6d29af |
| 출처 메모 | uspto-grants-1983_02 |