2-Azaspiro[5.5]undec-1-ene → 2-Azaspiro[5.5]undecane

HRID 1758810노트

반응식

HRID 1758810 반응식
[CH:1]1[C:6]2([CH2:11][CH2:10][CH2:9][CH2:8][CH2:7]2)[CH2:5][CH2:4][CH2:3][N:2]=1.[H][H]>[Ni].C(O)C>[CH2:1]1[C:6]2([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]2)[CH2:5][CH2:4][CH2:3][NH:2]1

참가 물질

5

반응물 2

HCID 18835922-Azaspiro[5.5]undec-1-eneHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 50061172-Azaspiro[5.5]undecane수율 88.1%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 702Ethanol용매

실험 절차

A solution of 2-azaspiro-[5.5]-undec-1-ene (15 g.; 0.10 mole) and one teaspoon (3 g.) of W2 Raney nickel catalyst in absolute ethanol (300 ml.) is hydrogenated at an initial pressure of 40 psi until hydrogen uptake ceases (2 hours). The mixture is filtered through celite and the filtrate concentrated under reduced pressure. Distillation of the residual liquid yields 88% of 2-azaspiro-[5.5]-undecane (13.5 g.), b.p. 55°-57° C./C.10 mm.

후처리

  1. filtrationThe mixture is filtered through celite
  2. concentrationthe filtrate concentrated under reduced pressure
  3. distillationDistillation of the residual liquid

출처 및 근거

ORD 기록
ord-ad75773f035f4f9c9d27151c877806ac
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04374991

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