2-Oxo-4-phenylbutyric acid → HCID 178445966, 화합물

HRID 1758848

반응식

HRID 1758848 반응식
O=[C:2]([CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:3]([OH:5])=[O:4].[NH2:14][C@H:15]([C:22]([NH:24][C@H:25]([C:30]([OH:32])=[O:31])[CH2:26][CH:27]([CH3:29])[CH3:28])=[O:23])[CH2:16][C:17]1[N:21]=[CH:20][NH:19][CH:18]=1.C([BH3-])#N.[Na+]>>[C:3]([CH:2]([NH:14][C@H:15]([C:22]([NH:24][C@H:25]([C:30]([OH:32])=[O:31])[CH2:26][CH:27]([CH3:28])[CH3:29])=[O:23])[CH2:16][C:17]1[N:21]=[CH:20][NH:19][CH:18]=1)[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([OH:5])=[O:4]

참가 물질

4

반응물 3

HCID 697322-Oxo-4-phenylbutyric acidHCID 5003444Sodium cyanoborohydrideHCID 178446018HCID 178446018, 화합물

생성물 1

HCID 178445966HCID 178445966, 화합물

실험 절차

In the manner described in example 24, one can condense 2-oxo-4-phenylbutyric acid and L-histidinyl-L-leucine in the presence of sodium cyanoborohydride to yield N-(1-carboxy-3-phenylpropyl)-L-histidinyl-L-leucine.

출처 및 근거

ORD 기록
ord-401b705fb87c464ea7c379801e327c41
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04374829

연결된 노트

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