4-Methyl-2-oxovaleric acid → HCID 178446426, 화합물

HRID 1758857

반응식

HRID 1758857 반응식
[CH3:1][CH:2]([CH3:9])[CH2:3][C:4](=O)[C:5]([OH:7])=[O:6].[NH2:10][C@H:11]([C:18]([NH:20][C@H:21]([C:26]([OH:28])=[O:27])[CH2:22][CH:23]([CH3:25])[CH3:24])=[O:19])[CH2:12][C:13]1[N:17]=[CH:16][NH:15][CH:14]=1.C([BH3-])#N.[Na+]>>[C:5]([CH:4]([NH:10][C@H:11]([C:18]([NH:20][C@H:21]([C:26]([OH:28])=[O:27])[CH2:22][CH:23]([CH3:24])[CH3:25])=[O:19])[CH2:12][C:13]1[N:17]=[CH:16][NH:15][CH:14]=1)[CH2:3][CH:2]([CH3:9])[CH3:1])([OH:7])=[O:6]

참가 물질

4

반응물 3

HCID 704-Methyl-2-oxovaleric acidHCID 5003444Sodium cyanoborohydrideHCID 178446018HCID 178446018, 화합물

생성물 1

HCID 178446426HCID 178446426, 화합물

실험 절차

In the manner decribed in Example 54, 4-methyl-2-oxopentanoic acid and L-histidyl-L-leucine are condensed in the presence of sodium cyanoborohydride to yield N-(1-carboxy-3-methylbutyl)-L-histidyl-L-leucine. In this case the product is eluted from the ion exchange resin with 10% ammonia. The mass spectrum shows a molecular ion at 408 m/e for the disilylated species minus 18. The nmr spectrum is consistent with structure.

출처 및 근거

ORD 기록
ord-31ab829602f643cc8b5c82f844374790
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04374829

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