Hydrochloric Acid → 2-(3-Chloro-2,2,3-trifluoropropionamido)-5-[2-(2,4-di-tert-pentylphenoxy)-butyramido]-phenol

HRID 1759586

반응식

HRID 1759586 반응식
[C:1]([C:6]1[CH:18]=[C:17]([C:19]([CH2:22][CH3:23])([CH3:21])[CH3:20])[CH:16]=[CH:15][C:7]=1[O:8][CH:9]([CH2:13][CH3:14])[C:10](Cl)=[O:11])([CH2:4][CH3:5])([CH3:3])[CH3:2].[Cl:24][CH:25]([F:40])[C:26]([F:39])([F:38])[C:27]([NH:29][C:30]1[CH:35]=[CH:34][C:33]([NH2:36])=[CH:32][C:31]=1[OH:37])=[O:28].N1C2C(=CC=CC=2)C=CC=1.Cl>O1CCOCC1>[Cl:24][CH:25]([F:40])[C:26]([F:38])([F:39])[C:27]([NH:29][C:30]1[CH:35]=[CH:34][C:33]([NH:36][C:10](=[O:11])[CH:9]([O:8][C:7]2[CH:15]=[CH:16][C:17]([C:19]([CH2:22][CH3:23])([CH3:21])[CH3:20])=[CH:18][C:6]=2[C:1]([CH2:4][CH3:5])([CH3:3])[CH3:2])[CH2:13][CH3:14])=[CH:32][C:31]=1[OH:37])=[O:28]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 7047QuinolineHCID 1703932-(2,4-Bis(1,1-dimethylpropyl)phenoxy)butyryl chlorideHCID 205313242-(3-Chloro-2,2,3-trifluoropropionamido)-5-aminophenol

생성물 1

HCID 205313212-(3-Chloro-2,2,3-trifluoropropionamido)-5-[2-(2,4-di-tert-pentylphenoxy)-butyramido]-phenol

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

A solution of 33.85 g (0.1 mole) of 2-(2,4-di-tert-pentylphenoxy)butyryl chloride in 80 ml of dioxan was added to a solution of 26.85 g (0.1 mole) of 2-(3-chloro-2,2,3-trifluoropropionamido)-5-aminophenol and 23.7 ml (0.2 mole) of quinoline in 500 ml of dioxan at room temperature. The mixture was stirred for 90 minutes and left standing overnight. Next it was poured out in 2 l of icewater and 100 ml of concentrated hydrochloric acid. The sticky residue was extracted with ether, rinsed with water until free from acid, and dried. The solvent was evaporated and the residue recrystallized from hexane.

후처리

  1. waitleft
  2. waitstanding overnight
  3. extractionThe sticky residue was extracted with ether
  4. washrinsed with water until free from acid
  5. customdried
  6. customThe solvent was evaporated
  7. customthe residue recrystallized from hexane

출처 및 근거

ORD 기록
ord-a5866f60b69b4438a7eb715e4469aa46
출처 데이터셋
uspto-grants-1982_07
특허 번호
US04341864

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