Dimethylformamide → Hydroxytetradecane Ether

HRID 1760052

반응식

HRID 1760052 반응식
[OH-].[Na+].[O:3]1[CH:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[CH2:4]1.[CH3:18]N(C)C=O>C1(C)C=CC=CC=1>[OH:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[CH3:6][CH2:5][O:3][CH2:4][CH3:18]

참가 물질

5

반응물 3

HCID 6228Dimethylformamide3회HCID 14798Sodium HydroxideHCID 186041,2-Epoxytetradecane

생성물 1

HCID 87205352Hydroxytetradecane Ether

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
150 °C

실험 절차

15.0 g (0.035 mol) of the polyerythritol prepared in Example 1 and 0.15 g of sodium hydroxide were dissolved in 20 ml of N,N-dimethylformamide while heating at 150° C. in a dried nitrogen gas flow, and stirred for 30 minutes. 14.8 g (0.070 mol) of 1,2-epoxytetradecane in 50 ml of N,N-dimethylformamide was added to the mixture, which was further stirred for four hours at 105° C. in a dried nitrogen gas flow. After the reaction, N,N-dimetylformamide was evaporated to obtain adcrude product. After dissolving the crude product in 100 ml of hot toluene and cooling the solution to room temperature, unreacted polyerythritol was filtered out. The toluene in the filtrate was evaporated in vaccuo to obtain 28.5 g of a white powdery desired product.

후처리

  1. stirringwas further stirred for four hours at 105° C. in a dried nitrogen gas flow
  2. customwas evaporated
  3. customto obtain adcrude product
  4. temperaturecooling the solution to room temperature
  5. filtrationunreacted polyerythritol was filtered out
  6. customThe toluene in the filtrate was evaporated in vaccuo

출처 및 근거

ORD 기록
ord-448d1fad38044f098b84c61bdd5a2c44
출처 데이터셋
uspto-grants-2005_01
특허 번호
US06838544B2

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