L-Leucine → (S)-4-isopropyloxazolidine-2,5-dione
반응식
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].Cl[C:11](Cl)([O:13]C(=O)OC(Cl)(Cl)Cl)Cl>C1COCC1>[CH3:5][CH:4]([CH2:3][CH:2]1[NH:1][C:11](=[O:13])[O:9][C:7]1=[O:8])[CH3:6]참가 물질
4
반응 조건
- 온도
- 45 °C
실험 절차
L-Leucine (15.00 g, 0.1144 mol) was heated to 100° C. under vacuum overnight, suspended in THF (150 ml) and stirred at 45° C. in a 3-neck flask with a reflux condenser fitted, under N2 pressure. Triphosgene (13.574 g, 0.4 eq) was added via a solid addition tube. After ca 80 min, the reaction had gone clear and the mixture was washed with dry diethyl ether (1 L) through the filter agent Celite (5 cm deep) in a sinter funnel (diameter 8 cm porosity 3) to a RB flask.
후처리
- customfitted, under N2 pressure
- waitAfter ca 80 min
- washthe mixture was washed with dry diethyl ether (1 L) through the filter agent Celite (5 cm deep) in a sinter funnel (diameter 8 cm porosity 3) to a RB flask
출처 및 근거
- ORD 기록
- ord-a2e22798bc27436f9dfbbd1951d8be33
- 출처 데이터셋
- uspto-grants-2005_01
- 특허 번호
- US06841689B2
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