Dimethylamine, hydrochloride → (5R)-2-[(2S)-2-(3,4-dichlorophenyl)-4-(dimethylamino)butyl]-1-oxo-1,2,3,4-tetrahydronaphtho[1,2-f][1,4]thiazepine-6-carbonitrile 5-oxide

HRID 1760956노트

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]([CH2:30][CH:31]=O)[CH2:10][N:11]2[C:17](=[O:18])[C:16]3[C:19]4[C:24]([CH:25]=[C:26]([C:27]#[N:28])[C:15]=3[S@:14](=[O:29])[CH2:13][CH2:12]2)=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[CH3:34][NH:35][CH3:36]>>[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]([CH2:30][CH2:31][N:35]([CH3:36])[CH3:34])[CH2:10][N:11]2[C:17](=[O:18])[C:16]3[C:19]4[C:24]([CH:25]=[C:26]([C:27]#[N:28])[C:15]=3[S@:14](=[O:29])[CH2:13][CH2:12]2)=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

반응물 2

HCID 10473Dimethylamine, hydrochloride

HCID 86759590(5R)-2-[(2S)-2-(3,4-dichlorophenyl)4-oxobutyl]-1-oxo-1,2,3,4-tetrahydronaphtho[1,2-f][1,4]thiazepine-6-carbonitrile 5-oxide

생성물 1

HCID 69140743(5R)-2-[(2S)-2-(3,4-dichlorophenyl)-4-(dimethylamino)butyl]-1-oxo-1,2,3,4-tetrahydronaphtho[1,2-f][1,4]thiazepine-6-carbonitrile 5-oxide수율 92.6%

실험 절차

By the method described in Example 79, Intermediate 78c (10 mg, 0.021 mmol) and dimethylamine hydrochloride (5 mg, 0.06 mmol) were converted to 10 mg of the title compound.

출처 및 근거

ORD 기록: ord-64bd30a16b4b4d9a84e1b460ab1f47d2
출처 데이터셋: uspto-grants-2005_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06846814B2

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