4-Fluoroaniline → N-[(1-acetyl-4-piperidinyl)methyl]-N'-(4-fluorophenyl)thiourea
반응식
[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][N:11]=[C:12]=[S:13])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[F:14][C:15]1[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1>O1CCCC1>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][NH:11][C:12]([NH:21][C:18]2[CH:19]=[CH:20][C:15]([F:14])=[CH:16][CH:17]=2)=[S:13])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]참가 물질
4
실험 절차
A mixture of 4 parts of 1-acetyl-4-(isothiocyanatomethyl)piperidine, 2.2 parts of 4-fluorobenzenamine and 90 parts of tetrahydrofuran was stirred overnight at reflux temperature. The reaction mixture was evaporated, yielding 6.2 parts (100%) of N-[(1-acetyl-4-piperidinyl)methyl]-N'-(4-fluorophenyl)thiourea as a residue (intermediate 12).
후처리
- temperatureat reflux temperature
- customThe reaction mixture was evaporated
출처 및 근거
- ORD 기록
- ord-6a1d8895bbe940f8b6de79e2386847b1
- 출처 데이터셋
- uspto-grants-1989_05
- 특허 번호
- US04826848
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