Methanol → HCID 14500560, 화합물

HRID 1761511노트

반응식

HRID 1761511 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[O:9])=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18].CO.[BH4-].[Na+]>C(O)(=O)C>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=2)[OH:9])=[CH:4][C:3]=1[N+:17]([O-:19])=[O:18]

참가 물질

5

반응물 3

HCID 887MethanolHCID 3015567(4-Amino-3-nitrophenyl)(4-fluorophenyl)methanoneHCID 4311764Sodium borohydride

생성물 1

HCID 14500560HCID 14500560, 화합물수율 99%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

To a stirred solution of 20 parts of (4-amino-3-nitrophenyl)(4-fluorophenyl)methanone in 120 parts of methanol were added 3.8 parts of sodium tetrahydroborate. The whole was stirred for 30 minutes at room temperature. 12 Parts of acetic acid were added and the mixture was stirred for 15 minutes. After evaporation, water was added to the residue. The product was extracted with 2,2'-oxybispropane. The extract was dried, filtered and evaporated, yielding 20 parts (99%) of 4-amino-α-(4-fluorophenyl)-3-nitrobenzenemethanol as a residue (int. 3).

후처리

  1. stirringthe mixture was stirred for 15 minutes
  2. customAfter evaporation, water
  3. additionwas added to the residue
  4. extractionThe product was extracted with 2,2'-oxybispropane
  5. customThe extract was dried
  6. filtrationfiltered
  7. customevaporated

출처 및 근거

ORD 기록
ord-44b28b883bb341a0a639fef30b3b7192
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04826862

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