Sodium borohydride → HCID 18632309, 화합물

HRID 1761638노트

반응식

HRID 1761638 반응식
Br.Cl.[CH3:3][CH:4]1[N:8]([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[C:7]2[CH:15]=[CH:16][CH:17]=[CH:18][C:6]=2[NH:5]1.Br[CH:20]1[CH2:28][C:27]2[C:22](=[CH:23][C:24]([O:31][CH3:32])=[C:25]([O:29][CH3:30])[CH:26]=2)[C:21]1=[O:33].[BH4-].[Na+]>C(Cl)(Cl)Cl.C(OCC)C>[CH3:3][CH:4]1[N:8]([CH:9]2[CH2:10][CH2:11][N:12]([C@H:20]3[CH2:28][C:27]4[C:22](=[CH:23][C:24]([O:31][CH3:32])=[C:25]([O:29][CH3:30])[CH:26]=4)[C@H:21]3[OH:33])[CH2:13][CH2:14]2)[C:7]2[CH:15]=[CH:16][CH:17]=[CH:18][C:6]=2[NH:5]1

참가 물질

5

반응물 3

HCID 4311764Sodium borohydrideHCID 109236312-Bromo-5,6-dimethoxy-indan-1-oneHCID 21242108HCID 21242108, 화합물

생성물 1

HCID 18632309HCID 18632309, 화합물수율 54.7%

시약·촉매·용매 1

HCID 21911965Chloroform ether용매

실험 절차

Prepared from 4-(2-methyl-1-benzimidazolinyl)-piperidine hydrochloride hydrobromide and 2-bromo-5,6-dimethoxy-1-indanone without isolation of the intermediate ketone and using NaBH4 as the hydrogenating agent. Yield 54.7%; m.p. 255°-256° C. (chloroform/diethyl ether).

출처 및 근거

ORD 기록
ord-b4a457abb48246209042232de91940a3
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04826975

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