Acetic Anhydride → N-(3-Chloro-4-fluorophenyl)acetamide
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[F:9])[NH2:5].[C:10](OC(=O)C)(=[O:12])[CH3:11]>O>[Cl:1][C:2]1[CH:3]=[C:4]([NH:5][C:10](=[O:12])[CH3:11])[CH:6]=[CH:7][C:8]=1[F:9]참가 물질
4
실험 절차
To 3-chloro-4-fluoroaniline (100 g) was slowly added acetic anhydride (200 ml). After allowed to stand for 30 minutes, the reaction mixture was poured into water (1 litter). The resulting precipitate was collected by filtration and recrystallized from aqueous ethanol to give the title compound (119.4 g), mp 118°-119° C.
후처리
- filtrationThe resulting precipitate was collected by filtration
- customrecrystallized from aqueous ethanol
출처 및 근거
- ORD 기록
- ord-5e5001753cee4cfdbeb924443d6973e6
- 출처 데이터셋
- uspto-grants-1989_05
- 특허 번호
- US04826982
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