N-(5-chloro-4-fluoro-2-nitrophenyl)acetamide → 5-Chloro-4-fluoro-2-nitroaniline

HRID 1761642노트

반응식

HRID 1761642 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:12]C(=O)C)[C:5]([N+:9]([O-:11])=[O:10])=[CH:6][C:7]=1[F:8]>Cl.C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]([N+:9]([O-:11])=[O:10])=[CH:6][C:7]=1[F:8])[NH2:12]

참가 물질

4

반응물 1

HCID 2773811N-(5-chloro-4-fluoro-2-nitrophenyl)acetamide

생성물 1

HCID 5178355-Chloro-4-fluoro-2-nitroaniline수율 101.3%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

실험 절차

A solution of N-(3-chloro-4-fluoro-6-nitrophenyl)acetamide (30 g) in concentrated hydrochloric acid (50 ml) and ethanol (200 ml) was refluxed for 2.5 hours. To the reaction mixture was added ice water (300 ml) and the resulting precipitate was collected by filtration, washed with water and dried to give the title compound (24.9 g) as yellow needles, mp 149.5°-150° C.

후처리

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed with water
  3. customdried

출처 및 근거

ORD 기록
ord-5910cdfdf8d448a4a349dea5664d92e6
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04826982

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