Sodium borohydride → HCID 14125980, 화합물

HRID 1761895노트

반응식

HRID 1761895 반응식
[BH4-].[Na+].[N:3]1([C:8]2([C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)=[O:12])[CH2:10][CH2:9]2)[CH:7]=[N:6][CH:5]=[N:4]1>CO>[F:19][C:16]1[CH:17]=[CH:18][C:13]([CH:11]([C:8]2([N:3]3[CH:7]=[N:6][CH:5]=[N:4]3)[CH2:10][CH2:9]2)[OH:12])=[CH:14][CH:15]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 13650453HCID 13650453, 화합물

생성물 1

HCID 14125980HCID 14125980, 화합물수율 89%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

1.2 g of sodium borohydride were added to a solution of 13.8 g (0.06 mol) of 4-fluorophenyl 1-(1, 2, 4-triazol-1-yl)-cyclopropyl ketone in 50 ml of methanol, the mixture was refluxed for 1 hour, and 12.4 g (89%) of the title compound, melting point 104°-106° C., were isolated by working up using dichloromethane/water.

후처리

  1. temperaturethe mixture was refluxed for 1 hour

출처 및 근거

ORD 기록
ord-e131b55d279147bb8503acfd61b50941
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04829075

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