Ammonium formate → 2-Phenylbenzofuran-7-carboxylic acid

HRID 1761905

반응식

HRID 1761905 반응식
Cl[C:2]1[CH:3]=[C:4]([C:17]([OH:19])=[O:18])[C:5]2[O:9][C:8]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:7][C:6]=2[CH:16]=1.C([O-])=O.[NH4+]>CO.[C].[Pd]>[C:10]1([C:8]2[O:9][C:5]3[C:4]([C:17]([OH:19])=[O:18])=[CH:3][CH:2]=[CH:16][C:6]=3[CH:7]=2)[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 142297055-Chloro-2-phenylbenzofuran-7-carboxylic acid

생성물 1

HCID 142297062-Phenylbenzofuran-7-carboxylic acid

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

반응 조건

온도
40 °C

실험 절차

1.46 g of 5-chloro-2-phenylbenzofuran-7-carboxylic acid are dissolved in a mixture of 15 ml of ethyleneglycol monomethylethers and 15 ml of methanol. 500 mg of 10% palladium-carbon and 1.6 g of ammonium formate are added to the solution and the solution is heated at 40° C. for 1.5 hours. The reaction mixture is filtered and the filtrate is concentrated under reduced pressure. The residue is dissolved in ethyl acetate. The solution is washed successively with 10% hydrochloric acid and water, dried and evaporated to remove solvent to give 2-phenylbenzofuran-7-carboxylic acid.

후처리

  1. filtrationThe reaction mixture is filtered
  2. concentrationthe filtrate is concentrated under reduced pressure
  3. dissolutionThe residue is dissolved in ethyl acetate
  4. washThe solution is washed successively with 10% hydrochloric acid and water
  5. customdried
  6. customevaporated
  7. customto remove solvent

출처 및 근거

ORD 기록
ord-b34affb6ac8946c39bb7e90c5008713e
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04829067

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