Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isopropanol → 2-(Diisopropylamino)ethyl 2-phenylbenzofuran-7-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 2-Chloroethyldiisopropylammonium chloride | HCID 77942 | — |
| 반응물 | 2-Phenylbenzofuran-7-carboxylic acid | HCID 14229706 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-(Diisopropylamino)ethyl 2-phenylbenzofuran-7-carboxylate | HCID 14229767 | 84.9% |
반응 단계
A mixture of 1.16 g of 2-phenylbenzofuran-7-carboxylic acid, 1.0 g of 2-(diisopropylamino)ethyl chloride hydrochloride, 0.66 g of potassium hydroxide and 20 ml of isopropanol is refluxed for 1 hour. After cooling, ethyl acetate and water are added to the reaction mixture. The organic layer is collected, washed with a saturated sodium chloride solution and evaporated to remove solvent. The residue is purified by silica gel column chromatography (solvent; chloroform:methanol=20:1) to give 1.51 g 2-(diisopropylamino)ethyl 2-phenylbenzofuran-7-carboxylate as colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04829067 |
| 출처 데이터셋 | uspto-grants-1989_05 |
| ORD ID | ord-3db9825a54ae4ac6bd36322a9eaf447b |
| 출처 메모 | uspto-grants-1989_05 |