反应详情

A mixture of 1.16 g of 2-phenylbenzofuran-7-carboxylic acid, 1.0 g of 2-(diisopropylamino)ethyl chloride hydrochloride, 0.66 g of potassium hydroxide and 20 ml of isopropanol is refluxed for 1 hour. After cooling, ethyl acetate and water are added to the reaction mixture. The organic layer is collected, washed with a saturated sodium chloride solution and evaporated to remove solvent. The residue is purified by silica gel column chromatography (solvent; chloroform:methanol=20:1) to give 1.51 g 2-(diisopropylamino)ethyl 2-phenylbenzofuran-7-carboxylate as colorless oil.

1. temperatureis refluxed for 1 hour
2. temperatureAfter cooling
3. customThe organic layer is collected
4. washwashed with a saturated sodium chloride solution
5. customevaporated
6. customto remove solvent
7. customThe residue is purified by silica gel column chromatography (solvent; chloroform:methanol=20:1)