Hydrochloric Acid → 2-(4-Nitrophenyl)benzofuran-7-carboxylic acid

HRID 1761926노트

반응식

HRID 1761926 반응식
[CH:1]([C:3]1[C:4]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=2)=[C:5]([CH:10]=[CH:11][CH:12]=1)[C:6]([O:8]C)=[O:7])=O.C[O-].[Na+].Cl>CN(C)C=O.CO>[N+:21]([C:18]1[CH:19]=[CH:20][C:15]([C:14]2[O:13][C:4]3[C:5]([C:6]([OH:8])=[O:7])=[CH:10][CH:11]=[CH:12][C:3]=3[CH:1]=2)=[CH:16][CH:17]=1)([O-:23])=[O:22]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 20043641Methyl 3-formyl-2-(4-nitrobenzyloxy)benzoate

생성물 1

HCID 142297282-(4-Nitrophenyl)benzofuran-7-carboxylic acid수율 59.8%

시약·촉매·용매 2

HCID 887Methanol용매HCID 6228Dimethylformamide용매

실험 절차

16.1 g of methyl 3-formyl-2-(4-nitrobenzyloxy)benzoate are dissolved in 100 ml of dimethylformamide and a solution of 5.4 g of sodium methoxide in 20 ml of methanol is added dropwise to the solution at 120° C. The mixture is stirred at the same temperature for 10 minutes. The reaction mixture is acidified with 10% hydrochloric acid and then extracted with ethyl acetate. The extract is washed with water, dried and evaporated to remove solvent. The resultant crystals are collected, washed and dried to give 8.65 g of 2-(4-nitrophenyl)benzofuran-7-carboxylic acid as pale orange powder.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe extract is washed with water
  3. customdried
  4. customevaporated
  5. customto remove solvent
  6. customThe resultant crystals are collected
  7. washwashed
  8. customdried

출처 및 근거

ORD 기록
ord-311ff26f9dfc4930a329f93cf2b18c57
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04829067

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