Sodium Hydroxide → 4-(2-(4-Isopropylbenzamido)ethoxy)benzoic acid

HRID 1762176

반응식

HRID 1762176 반응식
[CH:1]([C:4]1[CH:25]=[CH:24][C:7]([C:8]([NH:10][CH2:11][CH2:12][O:13][C:14]2[CH:23]=[CH:22][C:17]([C:18]([O:20]C)=[O:19])=[CH:16][CH:15]=2)=[O:9])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[OH-].[Na+]>C(O)C.O>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([C:8]([NH:10][CH2:11][CH2:12][O:13][C:14]2[CH:23]=[CH:22][C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=2)=[O:9])=[CH:24][CH:25]=1)([CH3:3])[CH3:2]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 14426623Methyl 4-[2-(4-isopropylbenzamido)ethoxy]benzoate

생성물 1

HCID 30810274-(2-(4-Isopropylbenzamido)ethoxy)benzoic acid수율 82%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

Methyl 4-[2-(4-isopropylbenzamido)ethoxy]benzoate (102.42 g) was dissolved in 1 liter of ethanol with heating. A solution of 14.4 g of sodium hydroxide in 200 ml of water was added to the above ethanolic solution and the mixture was heated to reflux for 2 hours. The reaction solution was concentrated in vacuo, 1 liter of ice water was added to the residue, the mixture was neutralized with 10% hydrochloric acid, crystals separated out therefrom were collected by filtration, washed with water, dried and recrystallized from ethanol to give 80.5 g (yield: 82%) of crystalline product. M.p. 202°-203° C.

후처리

  1. temperaturewith heating
  2. temperaturethe mixture was heated
  3. temperatureto reflux for 2 hours
  4. concentrationThe reaction solution was concentrated in vacuo, 1 liter of ice water
  5. additionwas added to the residue
  6. customseparated out
  7. filtrationtherefrom were collected by filtration
  8. washwashed with water
  9. customdried
  10. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-cd9d1d3528b84a1d8ba1aaf84c9f01c4
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04831055

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