Methanol → Dihydro-3-(2-hydroxyethyl)-2(3H)-furanone

HRID 1762287노트

반응식

HRID 1762287 반응식
[C:1](OC)(=[O:6])[CH2:2][C:3]([CH3:5])=O.[CH2:9]1[O:11][CH2:10]1.[Na+].[Cl-].C[OH:15]>>[OH:6][CH2:1][CH2:2][CH:3]1[CH2:5][CH2:10][O:11][C:9]1=[O:15]

참가 물질

5

반응물 4

HCID 887MethanolHCID 5234Sodium ChlorideHCID 6354Ethylene OxideHCID 7757Methyl acetoacetate

생성물 1

HCID 14047240Dihydro-3-(2-hydroxyethyl)-2(3H)-furanone수율 81%

반응 조건

온도
80 °C

실험 절차

A mixture of 58 g of methyl acetoacetate, 44 g of ethylene oxide, 3 g of NaCl and 70 ml of methanol was heated in an autoclave under autogenous pressure for 12 hours at 80° C. Thereafter, the methanol was distilled off, the residue was taken up with water, and the solution was washed with a little chloroform and distilled. 52.6 g of 2-(2-hydroxyethyl)-γ-butyrolactone were obtained, corresponding to a yield of 81% of theory.

후처리

  1. distillationThereafter, the methanol was distilled off
  2. washthe solution was washed with a little chloroform
  3. distillationdistilled

출처 및 근거

ORD 기록
ord-4d2ce2874c7f4713a848ac23a58f3fe2
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04831166

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