Hydrochloric Acid → HCID 20043143, 화합물

HRID 1762291노트

반응식

HRID 1762291 반응식
[CH3:1][NH:2][C:3]1[CH2:4][O:5][C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8](=[O:10])[CH:9]=1.[ClH:15]>CO>[ClH:15].[CH3:1][NH:2][C:3]1[CH2:4][O:5][C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8](=[O:10])[CH:9]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric Acid2회HCID 134460473-(Methylamino)-1-benzoxepin-5(2H)-one

생성물 1

HCID 20043143HCID 20043143, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

19 g 3-methylamino-1-benzoxepin-5(2H)-one were suspended in 130 ml methanol, and gaseous hydrogen chloride was introduced into the suspension with stirring in order to convert it into its hydrochloride. The amine thereby goes into solution with warming. Subsequently approximately 40 ml methanol were distilled from the solution. The solution was allowed to stand to crystallize the hydrochloride which was formed, and the crystals which formed were removed by filtration. 22 g 3-methylamino-1-benzoxepin-5(2H)-one hydrochloride were obtained which were used without further purification in the following hydrogenation.

후처리

  1. temperaturewith warming
  2. distillationSubsequently approximately 40 ml methanol were distilled from the solution
  3. customto crystallize the hydrochloride which
  4. customwas formed
  5. customthe crystals which formed
  6. customwere removed by filtration

출처 및 근거

ORD 기록
ord-a205a25a394b419c90fc37aa46f536ef
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04831167

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