Phosphorus oxychloride → 3-(Trifluoromethyl)phenylmethanesulfonyl chloride

HRID 1762297

반응식

HRID 1762297 반응식
[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[CH2:6][S:7]([O-])(=[O:9])=[O:8].[Na+].P(Cl)(Cl)([Cl:19])=O>>[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:11]=[CH:12][CH:13]=1)[CH2:6][S:7]([Cl:19])(=[O:9])=[O:8]

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 23700704Sodium 3-trifluoromethylbenzylsulfonate

생성물 1

HCID 27946463-(Trifluoromethyl)phenylmethanesulfonyl chloride수율 90.2%

실험 절차

10 g of sodium 3-trifluoromethylbenzylsulfonate was slowly added to 17.7 ml (29.1 g) of phosphorous oxychloride. The resulting slurry was stirred at 100° to 105° C. for five hours. The reaction mixture was then cooled and filtered. The filter cake was washed with methylene chloride, the washings were combined with the filtrate and then evaporated to dryness affording 8.9 g of 3-trifluoromethylbenzylsulfonyl chloride.

후처리

  1. temperatureThe reaction mixture was then cooled
  2. filtrationfiltered
  3. washThe filter cake was washed with methylene chloride
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-dda8beac658d4adba47334e9624a3721
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04831179

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