Sodium Carbonate → 4-(1,2,3-thiadiazol-4-yl)pyridine

HRID 1762689노트

반응식

HRID 1762689 반응식
[C:1](=[N:9][NH:10]C(N)=O)([C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1)[CH3:2].[S:14](Cl)(Cl)=O.C(=O)([O-])[O-].[Na+].[Na+]>C(Cl)(Cl)Cl>[S:14]1[CH:2]=[C:1]([C:3]2[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=2)[N:9]=[N:10]1

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 24386Thionyl ChlorideHCID 2755736HCID 2755736, 화합물

생성물 1

HCID 14718104-(1,2,3-thiadiazol-4-yl)pyridine

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

16.8 g of 4-acetylpyridine semicarbazone was added to 47 ml of thionyl chloride under ice-cooling, and, after allowing to warm to room temperature, the mixture was stirred for 1 hour. 200 ml of chloroform was added to the reaction mixture, and the resulting mixture was added dropwise to an aqueous solution of sodium carbonate cooled with ice. The chloroform layer was separated, washed with water, dried and concentrated to obtain 3.4 g of 4-(1,2,3-thiadiazol-4-yl)pyridine. Melting point: 121°-123° C.

후처리

  1. temperaturecooling
  2. temperaturecooled with ice
  3. customThe chloroform layer was separated
  4. washwashed with water
  5. customdried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-19d4b9ad136843178a319c19c55eddd8
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04833242

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