4-(1-Acetylpiperidin-4-yl)benzenesulphonamide → 4-Piperidin-4-YL-benzenesulfonamide

HRID 1762839노트

반응식

HRID 1762839 반응식
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([S:16]([NH2:19])(=[O:18])=[O:17])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C>Cl>[NH:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:15]=[CH:14][C:13]([S:16]([NH2:19])(=[O:17])=[O:18])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1

참가 물질

3

반응물 1

HCID 200398334-(1-Acetylpiperidin-4-yl)benzenesulphonamide

생성물 1

HCID 183484304-Piperidin-4-YL-benzenesulfonamide

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A mixture of the product of part (ii) above (17.0 g) and 5N aqueous hydrochloric acid (150 ml) was heated under reflux for 3 hours. The resulting solution was evaporated and the residue was dissolved in the minimum volume of water. The solution was made basic (to a pH of about 8-9) by the addition of solid sodium bicarbonate. The solid was filtered off, washed with a little water and crystallised from ethanol/methanol (2:1) to give the title compound, (7.70 g), m.p. 229°-230°.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 3 hours
  3. customThe resulting solution was evaporated
  4. dissolutionthe residue was dissolved in the minimum volume of water
  5. additionby the addition of solid sodium bicarbonate
  6. filtrationThe solid was filtered off
  7. washwashed with a little water
  8. customcrystallised from ethanol/methanol (2:1)

출처 및 근거

ORD 기록
ord-5746187191b3472e876e9aa341aac1a1
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04835165

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