Benzyl Chloride → N-Benzylcrotonamide

HRID 1763092

반응식

HRID 1763092 반응식
[C:1]([NH2:6])(=[O:5])/[CH:2]=[CH:3]/[CH3:4].[CH2:7](Cl)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CN(C)C=O>[CH2:7]([NH:6][C:1](=[O:5])/[CH:2]=[CH:3]/[CH3:4])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 7503Benzyl ChlorideHCID 53544872-Butenamide

생성물 1

HCID 2313079N-Benzylcrotonamide수율 71%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 200 ml of N,N-dimethylformamide, were added 17 g of crotonamide, 105 g of LEVATIT MP-500, which was also used in Example 68, and 32 g of benzylchloride. They were reacted at 50° C. for 4 hours with stirring. After the reaction, the reaction solution was treated in the same manner as in Example 69, the resulting distillation residue was recrystallized from benzine, and 25 of N-benzylcrotonamide having a melting point of 112.5°-113.6° C. was obtained (yield: 71%).

후처리

  1. customThey were reacted at 50° C. for 4 hours
  2. customAfter the reaction
  3. additionthe reaction solution was treated in the same manner as in Example 69
  4. distillationthe resulting distillation residue
  5. customwas recrystallized from benzine, and 25 of N-benzylcrotonamide having a melting point of 112.5°-113.6° C.
  6. customwas obtained (yield: 71%)

출처 및 근거

ORD 기록
ord-0d5f89ffa64b4db3a7c5df88b628343f
출처 데이터셋
uspto-grants-1989_05
특허 번호
US04835312

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