Hydrazinecarboxaldehyde → 6-(p-Bromophenyl)-1,2,4-triazolo[4,3-b]pyridazine

HRID 1763573

반응식

HRID 1763573 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[N:10][C:11](Cl)=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[CH:15]([NH:17][NH2:18])=O>C(O)CCC>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]3[N:10]([CH:15]=[N:17][N:18]=3)[N:9]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 12229HydrazinecarboxaldehydeHCID 64052553-(4-Bromophenyl)-6-chloropyridazine

생성물 1

HCID 227689336-(p-Bromophenyl)-1,2,4-triazolo[4,3-b]pyridazine

시약·촉매·용매 1

HCID 2631-Butanol용매

실험 절차

A mixture of 3.76 g. of 3-(p-bromophenyl)-6-chloropyridazine, 1.80 g of formylhydrazine and 50 ml. of butyl alcohol is heated to reflux and allowed to reflux overnight. The reaction mixture is allowed to cool and the precipitated product is washed with water, air dried and recrystallized from methyl alcohol, m.p. 209°-211° C.

후처리

  1. additionA mixture of 3.76 g
  2. temperatureto reflux
  3. temperatureto reflux overnight
  4. temperatureto cool
  5. washthe precipitated product is washed with water, air
  6. customdried
  7. customrecrystallized from methyl alcohol, m.p. 209°-211° C.

출처 및 근거

ORD 기록
ord-7345b9a48ba94d359060d8520e61b17e
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04112095

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