Hydrochloric Acid → L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride

HRID 1763725노트

반응식

HRID 1763725 반응식
[CH3:1][O:2][C:3](=[O:44])[C@H:4]([CH2:36][C:37]1[CH:42]=[CH:41][C:40]([OH:43])=[CH:39][CH:38]=1)[NH:5][C:6](=[O:35])[C@H:7]([CH2:33][OH:34])[NH:8][C:9](=[O:32])[C@H:10]([CH2:22][C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[NH:25][CH:24]=1)[NH:11]C(OCC1C=CC=CC=1)=O.CO.[ClH:47]>[Pd].O1CCCC1>[ClH:47].[CH3:1][O:2][C:3](=[O:44])[C@H:4]([CH2:36][C:37]1[CH:38]=[CH:39][C:40]([OH:43])=[CH:41][CH:42]=1)[NH:5][C:6](=[O:35])[C@H:7]([CH2:33][OH:34])[NH:8][C:9](=[O:32])[C@H:10]([CH2:22][C:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[NH:25][CH:24]=1)[NH2:11]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 54186548HCID 54186548, 화합물

생성물 1

HCID 70617527L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a mixture of 3.1 g. of Nα -benzyloxycarbonyl-L-trytophyl-L-seryl-L-tyrosine methyl ester and 200 mg. of 20% palladium on carbon is added 75 ml. of methanol containing 1.7 ml. of 3N hydrogen chloride in tetrahydrofuran and the reaction is stirred under an atmosphere of hydrogen for two and a half hours. The mixture is filtered to remove the catalyst and the filtrate is evaporated under reduced pressure to give a residue of L-tryptophyl-L-seryl-L-tyrosine methyl ester hydrochloride which is suitable for use without further purification.

후처리

  1. additionTo a mixture of 3.1 g
  2. filtrationThe mixture is filtered
  3. customto remove the catalyst
  4. customthe filtrate is evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-ff3903e65c1846ec828462fa69a4cdc2
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04111923

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