Sodium Hydroxide → 2-[p-(1-Cyclooctenyl)-phenoxy]-heptanoic acid

HRID 1764130

반응식

HRID 1764130 반응식
C([O:3][C:4](=[O:26])[CH:5]([O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH:19]=2)=[CH:14][CH:13]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])C.[OH-].[Na+]>C(O)C>[C:18]1([C:15]2[CH:14]=[CH:13][C:12]([O:11][CH:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH3:10])[C:4]([OH:26])=[O:3])=[CH:17][CH:16]=2)[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH:19]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 54549182alpha-[p-(1-Cyclooctenyl)-phenoxy]-heptanoic acid ethyl ester

생성물 1

HCID 542723602-[p-(1-Cyclooctenyl)-phenoxy]-heptanoic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 33 g of α-[p-(1-cyclooctenyl)-phenoxy]-heptanoic acid ethyl ester in 120 ml of ethanol are added 120 ml of 2N sodium hydroxide solutuion and the mixture is stirred for 11/2 hours at room temperature. The reaction mixture is then evaporated to dryness in vacuo and the residue partitioned between N hydrochloric acid and ether. The organic phase is washed until neutral, dried over sodium sulphate and evaporated to dryness in vacuo. The residue is crystallised from pentane to yield the 2-[p-(1-cyclooctenyl)-phenoxy]-heptanoic acid of the formula ##STR8## (m.p. 57°-60° C; b.p. 0.04 185°-188° C.

후처리

  1. customThe reaction mixture is then evaporated to dryness in vacuo
  2. customthe residue partitioned between N hydrochloric acid and ether
  3. washThe organic phase is washed until neutral,
  4. dry with materialdried over sodium sulphate
  5. customevaporated to dryness in vacuo
  6. customThe residue is crystallised from pentane

출처 및 근거

ORD 기록
ord-59a83047f9844651896f37969df9d72b
출처 데이터셋
uspto-grants-1978_09
특허 번호
US04115416

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