Acetic Acid → HCID 12875270, 화합물

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C=O.[ClH:3].[CH3:4][C:5]1[S:6][C:7]([Cl:11])=[CH:8][C:9]=1[Cl:10].[C:12](O)(=O)C>>[Cl:3][CH2:12][C:8]1[C:9]([Cl:10])=[C:5]([CH3:4])[S:6][C:7]=1[Cl:11]

참가 물질

반응물 4

HCID 176Acetic Acid

HCID 313Hydrochloric Acid

HCID 712Formaldehyde

HCID 128752653,5-Dichloro-2-methylthiophene

생성물 1

HCID 12875270HCID 12875270, 화합물

반응 조건

온도: 70 °C

실험 절차

8.6 G. (0.107 mol) off formalin and 90 ml. of concentrated hydrochloric acid were added to a solution of 10.87 g. (0.065 mol) of 2-methyl-3,5-dichlorothiophene in 45 ml. of acetic acid. The resulting mixture was heated to 70° C. for 18 hrs., cooled, poured into ice water and extracted with ether. The organic solution was washed with water, sodium bicarbonate and water, dried and evaporated to yield 3-chloromethyl-2,4-dichloro-5-methylthiophene as a crude oil.

후처리

temperature, cooled
extractionextracted with ether
washThe organic solution was washed with water, sodium bicarbonate and water
customdried
customevaporated

출처 및 근거

ORD 기록: ord-47d63f94b621427baf8d509b3ff27918
출처 데이터셋: uspto-grants-1978_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04116975

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