Hydrochloric Acid → 2-Chloro-5-(5-oxo-1,5-dihydro-[1,2,4]triazol-4-yl)-benzoic acid
반응식
[CH:1]([NH:3][NH:4][C:5]([NH:7][C:8]1[CH:13]=[C:12]([C:14]([O:16]C)=[O:15])[CH:11]=[CH:10][C:9]=1Cl)=[O:6])=O.[ClH:19]>[OH-].[K+].CO>[Cl:19][C:11]1[CH:10]=[CH:9][C:8]([N:7]2[C:5](=[O:6])[NH:4][N:3]=[CH:1]2)=[CH:13][C:12]=1[C:14]([OH:16])=[O:15]참가 물질
5
실험 절차
A solution of 1-formyl-4-(2-chloro-5-carbomethoxyphenyl)semicarbazide (0.03 g, 0.11 mmol) in 1.0 M KOH in methanol (MeOH) (0.44 mL) was heated at 80° C. for 72 hours and cooled to room temperature. 1.0 N HCl (0.8 mL) was added and the mixture evaporated to dryness in vacuo. The residue was taken up in MeOH (1.5 mL) and filtered. The filtrate was concentrated in vacuo to yield 0.028 g (100%) of the title intermediate as an amorphous solid. Mass Spectrum (M−H): 3:1 ratio of 238 and 240.
후처리
- customthe mixture evaporated to dryness in vacuo
- filtrationfiltered
- concentrationThe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-f86256d62a1c4dbfb05d7cc9aef022f1
- 출처 데이터셋
- uspto-grants-2007_06
- 특허 번호
- US07235549B2
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