Hydrogen Peroxide → 3-(2-Acetoxymethyl-pyridin-4-yl)-benzoic acid methyl ester
반응식
[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH3:16])[CH:11]=2)[CH:5]=1.OO>C(O)(=O)C.C(OC(=O)C)(=O)C>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH2:16][O:17][C:3](=[O:2])[CH3:4])[CH:11]=2)[CH:5]=1참가 물질
5
실험 절차
Oxidation of 3-(2-methyl-pyridin-4-yl)-benzoic acid methyl ester (26.2 g, 0.11 mol; K4) with H2O2 (30%, 31.5 ml, 0.31 mol) in acetic acid (117 ml) at 70° C. for 27 h and subsequent reaction of the N-oxide in acetic acid anhydride (22 ml) at 135° C. for 30 min yielded after aqueous work-up 3-(2-acetoxymethyl-pyridin-4-yl)-benzoic acid methyl ester.
출처 및 근거
- ORD 기록
- ord-46e7c36d54cc4b5cac19489336faf421
- 출처 데이터셋
- uspto-grants-2007_06
- 특허 번호
- US07235547B2
반응 노트
불러오는 중…